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Any product legal responsibility claim brought in opposition to us, with or with out advantage, could lead to: • withdrawal of scientific trial volunteers, investigators, sufferers or trial websites or limitations on permitted indications; • the inability to commercialize, or if commercialized, decreased demand for, our product candidates; 36 • if commercialized, product remembers, withdrawals of labeling, advertising or promotional restrictions or the need for product modification; • initiation of investigations by regulators; • lack of revenues; • substantial prices of litigation, including financial awards to sufferers or other claimants; • liabilities that substantially exceed our product liability insurance coverage, which we’d then be required to pay ourselves; • an increase in our product liability insurance coverage rates or the lack to maintain insurance coverage coverage in the future on acceptable phrases, if at all; • the diversion of administration’s attention from our business; and • damage to our reputation and the popularity of our products and our know-how. Chapter 15 Submandibular Region and Floor of Mouth 231 Table 15-1 Suprahyoid Muscles and Extrinsic Muscles of the Tongue Muscle Origin Insertion Innervation Action Posterior belly Mastoid notch Intermediate tendon Facial nerve Posterior belly: draws of digastric of temporal bone hyoid bone posteriorly Anterior belly Digastric fossa Intermediate tendon Mandibular division Anterior belly: attracts hyoid of digastric of mandible of trigeminal bone anteriorly Both bellies: elevates hyoid bone and open mandible when hyoid bone is fixed Stylohyoid Styloid course of Body of hyoid bone Facial nerve Draws the hyoid bone supe (posterior and riorly and posteriorly; additionally lateral surfaces) assists in fixing the hyoid bone Mylohyoid Mylohyoid line Median raphe (anterior Mylohyoid nerve Depresses mandible of the mandible fibers) and the physique (mandibular division (when hyoid bone is fastened); of the hyoid bone of trigeminal nerve) elevates the hyoid bone (posterior fibers) (when the mandible is mounted) Geniohyoid Inferior psychological backbone Body of the hyoid Cl (transported by the Draws hyoid bone of the mandible bone hypoglossal nerve) anteriorly Genioglossus Superior mental backbone From the tip to the back Hypoglossal nerve Protrudes the tongue of the mandible of the tongue (also physique and depresses the tip of the hyoid bone) of the tongue Hyoglossus Body and higher cornu Body of the tongue Hypoglossal nerve Depresses the tongue of the hyoid bone Styloglossus Styloid course of (anterior Body of the tongue Hypoglossal nerve Retracts the tongue floor) and styloman to the tip of the tongue and elevates its tip dibular ligament Palatoglossus Fascia and lateral facet Side of the tongue Pharyngcal plexus Elevates root of the tongue of soppy palate and constricts the fauces the digastric muscle consists of two parts: a pos the mandibular arch (pharyngeal arch I) and is inner terior belly, which arises from the mastoid notch of vated by a branch of the mylohyoid nerve from the the temporal bone, and an anterior belly, arising from mandibular division of the trigeminal nerve. 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